Fisiopatologia da Toxina Botulínica na Junção Neuromuscular

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Full transcript

Um neurônio motor envia um impulso até sua terminação nervosa. O cálcio entra, as vesículas com acetilcolina se fundem à membrana e liberam o neurotransmissor na fenda sináptica, que se liga aos receptores da fibra muscular, ativando a contração. A toxina botulínica interfere nas proteínas SNARE da terminação nervosa, impedindo a fusão das vesículas com a membrana. Isso bloqueia a liberação de acetilcolina, reduzindo a ativação dos receptores na fibra muscular. Sem acetilcolina suficiente, a transmissão neuromuscular falha, causando fraqueza muscular e paralisia flácida. Em resumo: impulso nervoso, entrada de cálcio, liberação de acetilcolina, bloqueio pela toxina nas proteínas SNARE, e redução da ativação muscular.

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