Hemoglobin-Based Oxygen Carriers
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Hemoglobin is the blood component that carries oxygen from lungs to tissues and returns carbon dioxide. Since donor blood has limited shelf life, storage needs, and infection risks, scientists developed Hemoglobin-Based Oxygen Carriers, or HBOCs, as alternatives. HBOCs come as cell-free carriers or encapsulated ones protected inside liposomes. They work by binding oxygen in the lungs, circulating through blood, releasing oxygen into tissues, and supporting cellular metabolism, just like natural hemoglobin, making them useful in emergencies, severe blood loss, and surgery. However, HBOCs face toxicity risks, oxidative stress, and kidney damage, along with stability challenges that can weaken oxygen binding. In conclusion, HBOCs remain a promising alternative for oxygen delivery, though further research is needed to ensure their safety and effectiveness. Thank you.
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