How Does a Painkiller Know Where It Hurts?
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How does a painkiller "know" where it hurts? Swallowed with water, the tablet dissolves in the stomach, moves to the small intestine, and enters tiny blood vessels. It passes through the liver, then spreads through the whole body within thirty to sixty minutes. When tissue is injured, damaged cells release an enzyme called COX-2, producing prostaglandins. These make nerve endings more sensitive, sending stronger pain signals, and widen blood vessels, causing redness, warmth, and swelling. The painkiller blocks COX enzymes right where inflammation is highest, reducing prostaglandins so pain and swelling fade. Later, the liver breaks it down and the kidneys clear it, so once levels drop, COX activity returns—meaning the dose must be repeated until the injury heals.
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